CENTENARIANS AND HIGH ADIPONECTIN LEVELS

FGF21 (the starvation hormone) FASTING & LONGEVITY

Fibroblast growth factor-21 (FGF21) is a hormone secreted by the liver during fasting that elicits diverse aspects of the adaptive starvation response. Among its effects, FGF21 induces hepatic fatty acid oxidation and ketogenesis, increases insulin sensitivity, blocks somatic growth and causes bone loss. Here we show that transgenic overexpression of FGF21 markedly extends lifespan in mice without reducing food intake or affecting markers of NAD+ metabolism or AMP kinase and mTOR signaling. Transcriptomic analysis suggests that FGF21 acts primarily by blunting the growth hormone/insulin-like growth factor-1 signaling pathway in liver. These findings raise the possibility that FGF21 can be used to extend lifespan in other species.

FGF21 is specifically induced by HMGCS2 activity. The oxidized form of ketone bodies (acetoacetate) in a cultured medium also induced FGF21, possibly via a SIRT1-dependent mechanism.[3] HMGCS2 activity has also been shown to be increased by deacetylation of lysines 310, 447, and 473 via SIRT3 in the mitochondria.[4]

While FGF21 is expressed in numerous tissues, including liver, brown adipose tissue, white adipose tissue and pancreas, circulating levels of FGF21 are derived specifically from the liver in mice.[5] In liver FGF21 expression is regulated by PPARα and levels rise substantially with both FASTING and consumption of ketogenic diets.

SOURCE: HERE

FULVIC ACID and the importance of minerals

Watch the light bulb demonstration: Www.purefulvicminerals.com

Your body is just like a battery; no minerals—no electricity. “All life is Electric”.

(CONTINUED IN THE NEXT BLOG “A CONCEPTUAL REVOLUTION OF BIBLICAL PROPORTIONS”)