“Fasting resulted in reduced plasma glucose concentrations compared with the control study, while dehydration resulted in increased plasma glucose concentrations compared with the control study. Glucose production and disposal were decreased during the fasting study and increased during the dehydration study compared with the control study.

***Glucagon concentrations and rates of development of ketosis and metabolic acidosis were increased during both fasting and dehydration compared with control.***

These data suggest that fasting and dehydration have differential effects on glycemia during insulin deficiency, with dehydration favoring the development of hyperglycemia and fasting resulting in reduced glucose concentrations.”

Read HERE

Here’s the numbers:

Dry fasting = Ketosis in 12-24 hours

Water fasting = Ketosis in 48-72 hours.

Test it and see for yourself.

Get ketostix HERE

What is Glucagon?

Glucagon is a peptide hormone, produced by alpha cells of the pancreas. It works to raise the concentration of glucose in the bloodstream. Its effect is opposite that of insulin, which lowers the glucose.

Why is KETOSIS important and what is it’s link to autophagy, mTOR inhibition, AMPK activation?

Answer: HERE

CALORIE RESTRICTION AND ITS EFFECTS ON AGING

What is MTOR  

​”mTOR forms two functional complexes, C1 and C2.  The C1 complex is more significant in health and disease.  mTOR responds to signals from nutrients, growth factors, and cellular energy status and controls cell growth and proliferation based on this (by regulating protein synthesis).

In more simple English, whenever we have lots of nutrition (mainly protein) and calories we essentially tell the body that plentiful times are here.   We are ready to kick some ass and hunt some animal. Our cells increase their working capacity and ATP production is increased.  Cells increase division and  we are primed for growth and repair.  mTOR is the protein that senses this and puts ‘the pedal to the metal’.

However, in times of any stress such as reduced caloric or nutrient intake, mTOR is inhibited (R).

It’s important to realize that mTOR can increase performance and we shouldn’t view it as either good or bad.  It more like depends.

mTOR is one of those things that’s good to have cycled.  Sometimes we want to increase it to grow muscle and improve certain aspects of cognition, while the rest of the time want to have low levels to increase longevity, decrease cancer risk and decrease inflammation.

You see, mTOR increases energy production, but also creates more junk products.

Autophagy is the process that degrades these junk products.  But it is only usually active when mTOR is decreased.  In other words, the body doesn’t start cleaning up until the party is over.

Autophagy is equivalent to a ‘detox’ from a scientific perspective.  We need a balance between growth/junk products and rest/cleanup.”

SOURCE: HERE

(THIS DISCUSSION IS CONTINUED IN THE NEXT BLOG TITLED “WHAT IS AMPK?”)