P53: THE ANTI-TUMOR GENE AND FASTING

What is P53?

P53, also known as TP53 or tumor protein (EC :2.7.1.37) is a gene that codes for a protein that regulates the cell cycle and hence functions as a tumor suppression. It is very important for cells in multicellular organisms to suppress cancer.

“Our findings that CR or a 1 day/week fast suppressed carcinogenesis—even when started late in life in mice predestined to develop tumors due to decreased p53 gene dosage—support efforts to identify suitable interventions influencing energy balance in humans as a tool for cancer prevention.”

SOURCE: HERE

GHRELIN

Ghrelin the anti-aging hunger hormone is released about 12 hours after your last meal. This is why you want lots of Ghrelin: READ

But what about lack of water and kidneys?

“High fluid intake does not appear to slow renal disease progression in humans.”

SOURCE: HERE

PROTECT KIDNEYS by ALKALINIZING periodically before and after dry fasts

with a simple teaspoon of BAKING SODA in water.

“Oral Hydration and Alkalinization is Noninferior to Intravenous Therapy for Prevention of Contrast-Induced Nephropathy in Patients with Chronic Kidney Disease”

SOURCE: HERE

HEADACHES are common on the first day for new dry fasters and those not experienced with KETOSIS. It usually takes place around the 18 hour mark and goes away after a few hours. This is the brain switching off glucose and now using ketones for fuel. The headache could also be symptomatic of caffeine withdrawal. Totally normal; push through, it passes.

50% INCREASE IN LIFESPAN —BY COMPLETE ABSENCE OF FOOD

“Remarkably, the greatest increase in lifespan was observed …maintained in the complete absence of food, with a 50% increase in median and maximum lifespan relative to control-fed animals.”

SOURCE: HERE

INCREASES LIFESPAN UP TO 60%

“Dietary Restriction (DR) increases the rodent lifespan by up to 60% in part by delaying the occurrence of many chronic diseases, and in part by slowing the rate of biological or physiological aging (1).

Among its many protective effects of DR described in mice, the most notable include those on increasing insulin sensitivity and on the attenuation of B amyloid deposition in a model for Alzheimer’s Disease (54). Severe dietary restriction or STARVATION (dry fasting) may also be applicable to disease treatment. For example, fasting protects mice against high dose chemotherapy in part by reducing serum IGF-I signalling but does not protect cancer cells, since oncogene mutations prevent the activation of the stress resistance pathways in response to the reduction in glucose, IGF-I and other growth factors caused by nutrient deprivation (55).”

SOURCE: HERE

“The higher the metabolism speed, the shorter the lifespan, and vice versa.”

YOU DO NOT WANT A FAST METABOLISM.

SOURCE: HERE

Over 24 weeks, a low-carbohydrate diet program led to greater weight loss, reduction in serum triglyceride level, and increase in HDL cholesterol level compared with a low-fat diet.

THE STARVATION TREATMENT OF DIABETES

ADHD AND FASTING AS A CURE

Adiponectin is associated with longevity and heightened insulin sensitivity and has anti cancer properties; it is a hormone excreted primarily from adipose tissue(fat). Fasting is exceptional for releasing Adiponectin and preventing adhd not to mention inhibiting disease and prolonging life.

SOURCE: HERE

(CONTINUED IN THE NEXT BLOG TITLED “CENTENARIANS AND HIGH ADIPONECTIN LEVELS“)